Srikanth blew two game points in the second game to lose 7-21, 20-22 to Axelsen in the men's singles summit clash.
India ace Kidmabi Srikanth clinched his third Super Series Premier title with a dominating straight-game victory over Korean veteran Lee Hyun II in a lop-sided final of the US $750,000 Denmark Open, in Odense, on Sunday.
Saina Nehwal, who won a bronze at the World Championship, jumped four rungs to be placed at the 12th spot, while Kidambi Srikanth also improved two positions in the latest BWF World ranking.
While Olympic and two-time World Championship silver medallist, Sindhu stamped her authority with a 21-12, 21-15 win over Thailand's Busanan Ongbamrungphan in the second round, Srikanth got the better off Indonesia's Tommy Sugiarto in a three-game match.
Thomas Cup final: India vs Indonesia
Defending champions India sailed to the knockout stage of the Thomas Cup with a 5-0 rout of England.
Saina dropped two spots to third in the women's singles list, and is placed below Spaniard Carolina Marin (80752), who rose a rung following her Australian Open title triumph.
PV Sindhu and Kidambi Srikanth advanced into the second round while Saina Nehwal and Sai Praneeth made first-round exits at the All England Open Badminton Championships in Birmingham on Wednesday.
The star Indian pair of Chirag Shetty and Satwiksairaj Rankireddy will be the key attraction in the men's doubles category. However, they are set to face a stiff competition as the line-up includes the three-time world champion and world No. 2 Indonesian duo of Mohammad Ahsan and Hendra Setiawan alongside another Indonesian pair of Fajar Alfian and Muhammad Rian Ardianto, who are currently ranked eighth in the world.
Double Olympic medallist P V Sindhu stayed on course for an elusive gold medal, while Laskhya Sen entered his maiden final at the Commonwealth Games in Birmingham on Sunday.
The Indian men's team is searching for its maiden medal at the tournament. No Indian men's team has ever reached the semi-finals of the Thomas Cup.
Srikanth held a 4-1 record over Prannoy coming into this match, but the shuttler was unable to deliver. Srikanth won the first game 21-13, but Prannoy won the second set comprehensively.
The top Indian players, including Sindhu, Saina Nehwal and Srikanth have failed to lift the prestigious trophy
A recap of the performance by Indian athletes on Day 10 at the Rio Olympics on Monday
Indian shuttler H S Prannoy continued his giant-killing spree to stun World and Olympic Champion Chen Long of China to enter the semi-finals of the Indonesia Super Series Premier along with Kidambi Srikanth, in Jakarta, on Friday.
P V Sindhu suffered her fourth successive defeat to the young An Seyoung as she signed off her women's singles campaign at the semi-final stage of the Korea Open Super 500 badminton tournament in Suncheon (South Korea), on Saturday.
The top-16 in the world by April-end will make the cut for the Olympics.
Prannoy reached the World Championships on previous two occassions.
Indian shuttlers Saina Nehwal, Kidambi Srikanth and Sameer Verma also advanced to the second round of the $550,000 tournament at the Barclaycard Arena.
India's top badminton players Saina Nehwal and Kidambi Srikanth took a big step on way to reaching the semi-finals at the World Super Series Finals by securing second consecutive wins in their respective group in Dubai.
Sindhu progressed to the quarterfinals with an easy straight-game win over Japan's Aya Ohori
Swiss Open champion Satwiksairaj Rankireddy and Chirag Shetty strengthened their world number six position, while women's doubles pairing of Treesa Jolly and Gayatri Gopichand was static at the 18th position.
Fourth seeded Sindhu took 39 minutes to get the better of World No 22 Mia 21-13, 21-19, her second straight win over the Dane.
Sindhu pulls out of Uber Cup
Indian shuttlers P V Sindhu and Kidambi Srikanth crashed out in the group stages after losing their respective second round matches in the BWF World Tour Finals, in Bangkok, on Thursday.
Saina Nehwal was the lone Indian left in the Australian Open Super Series badminton tournament after a hard-fought victory over China's Sun Yu in Sydney on Thursday. The world No 1 overcame a stiff challenge from Yu, ranked No 9, winning 21-19, 19-21, 21-14 in 78 minutes.
Defending champion P Kashyap bowed out while top seed K Srikanth entered the semi-finals but it was the stunning win of doubles pair of Pranaav Jerry Chopra and Akshay Dewalkar over their World No 8 opponents from Denmark that was the highlight of the day at Syed Modi Grand Prix Gold badminton tournament, in Lucknow, on Friday.
World number one Saina Nehwal disposed off Nichaon Jindapon's challenge in straight games, but PV Sindhu crashed out of the Indonesian Open Super Series badminton tournament after a close first-round defeat, in Jakarta, on Wednesday. In the men's singles, both the Indians in the fray -- Parupalli Kashyap and Kidambi Srikanth -- advanced to the second round with contrasting victories.
Karnataka Chief Minister Basavaraj Somappa Bommai was quick to felicitate the 20-year-old native of Almora in Uttarkhand who is now based in Bengaluru where he trains at the Prakash Padukone Badminton Academy.
Former champions P V Sindhu and Kidambi Srikanth stayed on course to reclaim titles while a vintage Parupalli Kashyap too regained some form to seal places in the men's singles semi-finals of the US $350,000 India Open badminton, in Delhi, on Friday.
Lakshya Sen recorded another comfortable win but double Olympic medallist P V Sindhu and Kidambi Srikanth had to work hard to enter the semi-finals
It was double delight for India as crowd favourites Saina Nehwal and Kidambi Srikanth clinched their maiden women and men's singles titles at the India Open Super Series badminton tournament in New Delhi.
Olympic silver medallist P V Sindhu yet again struggled to go past China's He Bingjiao and bowed out of the China Open World Tour Super 750, in Fozhou, on Friday.
Treesa Jolly and Gayatri Gopichand entered the quarter-finals of the Swiss Open Badminton Championship with a straight-game victory over Germany's Amelie Lehmann and Selin Hubsch.
It was Saina Nehwal's 13th straight defeat against the World No 1 Taiwanese, whom she has not beaten since 2015.
The Indian duo won 21-15, 21-13.
Olympic medallist P V Sindhu is also missing in action as she recovers from an injury.
None of the other three quarters boast of such a strong star cast but there would be a few mouth-watering opening round clashes to look forward to.
PV Sindhu survived a scare against Hong Kong's Cheung Ngan Yi before prevailing 19-21, 23-21, 21-17 in a thrilling singles match that lasted an hour and 27 minutes.
Double Olympic medallist PV Sindhu will spearhead the women's challenge in both the Commonwealth and Asian Games while London Olympics bronze winner Saina Nehwal did not expectedly feature in the squads.